NMR Spectroscopy–Based Metabolic Profiling of Biospecimens

NMR-based plasma metabolic profiling in patients with unstable angina

Objective(s): Unstable angina (UA) is a form of the acute coronary syndrome (ACS) that affects more than a third of the population before age 70. Due to the limitations of diagnostic tests, appropriate identification of UA is difficult. In this study, we proceeded to investigate metabolite profiling in UA patients compared with controls to determine potential candidate...

NMR metabonomic study of lung cancer: metabolic profiling of tissues

This work aims to evaluate the potential of H Nuclear Magnetic Resonance (NMR) spectroscopy combined with multivariate statistics (metabonomics) for finding malignancy biomarkers in lung tissue and discriminating between different tumour histological types. Paired tissue samples from 32 patients with primary lung cancer were directly analysed by H High Resolution Magic Angle Spinning (HRMAS) NM...

1H-NMR, 1H-NMR T2-edited, and 2D-NMR in bipolar disorder metabolic profiling

BACKGROUND The objective of this study was to identify molecular alterations in the human blood serum related to bipolar disorder, using nuclear magnetic resonance (NMR) spectroscopy and chemometrics. METHODS Metabolomic profiling, employing 1H-NMR, 1H-NMR T2-edited, and 2D-NMR spectroscopy and chemometrics of human blood serum samples from patients with bipolar disorder (n = 26) compared wit...

Evaluation of high resolution magic-angle coil spinning NMR (HR-MACS-NMR) spectroscopy for metabolic profiling of nanoliter tissue biopsies

Toxicological effect of thallium in mice by NMR-based metabolic profiling of urine

INTRODUCTION: Thallium is a heavy metal that is used in the manufacture of electronic components, optical lenses, semiconductor materials, alloys, gamma radiation detection equipment, imitation jewelry, artist's paints, low temperature thermometers, and green fireworks. Cigarette smoking is also a source of thallium. After absorption, it gets accumulated in liver and kidney and causes renal and...